Table 3.

Test of synergy in T24 xenografts for in vivo to in vitro clonogenicity with radiation and amprenavir or radiation and nelfinavir

Log10 plating efficiency mean * ± SD (no. measures per mouse)
Control (n = 5)6 Gy (n = 3)Amprenavir (n = 3)6 Gy + Amprenavir (n = 4)Nelfinavir (n = 3)6 Gy + Nelfinavir (n = 2)
−0.62 ± 0.03 (12)−1.80 ± 0.15 (12)−0.85 ± 0.17 (12)−2.45 ± 0.39 (11-12)−0.93 ± 0.09 (12)−2.60 ± 0.25 (12)
Interaction term β (SE)−0.420 (0.239)−0.499 (0.138)
Wald statistic−1.760−3.621
Test of synergy (one-sided P)0.0530.003
  • * Mean of the averages for each mouse.