Table 4.

Test of synergy for regrowth delay in time to reach tumor volume of 1,000 mm3 in SQ20B xenografts ± nelfinavir after radiation

Days to tumor volume of 1,000 mm3 mean ± SD (range)
Control (n = 6)Nelfinavir (n = 6)8 Gy (n = 5)8 Gy + Nelfinavir (n = 5)
11.0 ± 1.5 (10-13)12.0 ± 1.5 (10-13)15.0 ± 2.0 (13-17)41.0 ± 30.3 (17-78)
Interaction term β (SE)25.000 (12.321)
Wald statistic2.029
Test of synergy (one-sided P)0.03
  • NOTE: All animals reached tumor volume of 1,000 mm3 before sacrifice.