Table 5.

Test of synergy for regrowth delay in time to reach tumor volume of 1,000 mm3 in SQ20B xenografts ± amprenavir after radiation

Days to tumor volume of 1,000 mm3 mean ± SD (range)
Control (n = 5)Amprenavir (n = 7)8 Gy (n = 5)8 Gy + Amprenavir (n = 5)
5.8 ± 1.6 (4-7)7.1 ± 2.0 (4-11)8.0 ± 3.0 (4-11)15.8 ± 3.4 (11-20)
Interaction term β (SE)6.457 (2.211)
Wald statistic2.920
Test of synergy (one-sided P)0.0045
  • NOTE: All animals reached tumor volume of 1,000 mm3 before sacrifice.