Table 6.

Test of synergy for regrowth delay in time to reach tumor volume of 1,000 mm3 in T24 xenografts ± amprenavir after radiation

Days to tumor volume of 1,000 mm3 mean ± SD (range)
Control (n = 5)Amprenavir (n = 6)6 Gy (n = 6)6 Gy + Amprenavir (n = 5)
15.8 ± 3.2 (11-18)13.2 ± 4.4 (7-18)19.3 ± 2.1 (18-22)30.8 ± 4.0 (26-35 *)
Interaction term β (SE)14.100 (3.006)
Wald statistic4.691
Test of synergy (one-sided P)<0.001
  • * One animal did not reach a tumor volume of 1,000 mm3 during observation period.