Table 7.

Test of synergy for regrowth delay in time to reach tumor volume of 1,000 mm3 in T24 xenografts ± nelfinavir after radiation

Days to tumor volume of 1,000 mm3 mean ± SD (range)
Control (n = 5)Nelfinavir (n = 6)6 Gy (n = 6)6 Gy + Nelfinavir (n = 5)
15.8 ± 3.2 (11-18)14.3 ± 3.1 (11-18)19.3 ± 2.1 (18-22)28.6 ± 7.1 (18-35 *)
Interaction term β (SE)10.733 (3.569)
Wald statistic3.007
Test of synergy (one-sided P)0.004
  • * One animal did not reach a tumor volume of 1,000 mm3 during observation period.