Table 1.

The effect of phenethyl isothiocyanate, sulforaphane, and their N-acetylcysteine conjugates on the progression of lung tumorigenesis in A/J mice treated with and without NNK and B(a)P

GroupNumber of miceAdenomasAdenocarcinomas
At beginningAt terminationTumors/mouse (mean ± SD)Incidence (%)Tumors/mouse (mean ± SD)Incidence (%)
NNK + B(a)P–treated
    1. Control3999.4 ± 5.51001.0 ± 1.542
    2. Phenethyl isothiocyanate (3 μmol/g)3258.7 ± 3.91000.4 ± 0.9 *19 *
    3. Phenethyl isothiocyanate (1.5 μmol/g)2087.3 ± 4.5951.2 ± 1.935
    4. Sulforaphane (3 μmol/g)3268.9 ± 6.1930.8 ± 1.528
    5. Sulforaphane (1.5 μmol/g)2089.3 ± 4.21000.3 ± 0.7 *20
    6. Phenethyl isothiocyanate-N-acetylcysteine (8 μmol/g)3298.3 ± 4.0960.5 ± 1.513 *
    7. Phenethyl isothiocyanate-N-acetylcysteine (4 μmol/g)2088.2 ± 3.7950.5 ± 1.221
    8. Sulforaphane-N-acetylcysteine (8 μmol/g)32119.7 ± 5.41000.4 ± 1.0 *16 *
    9. Sulforaphane-N-acetylcysteine (4 μmol/g)2098.5 ± 4.4950.3 ± 1.0 *11 *
Untreated
    10. Phenethyl isothiocyanate (3 μmol/g)552.0 ± 3.9400.0 ± 0.00
    11. Sulforaphane (3 μmol/g)550.0 ± 0.000.0 ± 0.00
    12. Phenethyl isothiocyanate-N-acetylcysteine (8 μmol/g)550.3 ± 0.0250.0 ± 0.00
    13. Sulforaphane-N-acetylcysteine (8 μmol/g)540.2 ± 0.5200.0 ± 0.00
    14. Untreated550.2 ± 0.5200.0 ± 0.00
  • * P< 0.05 compared with control after adjustment for survival time.