Table 1.

Transformed and tumorigenic phenotypes of engineered tumor cells

Ma6−RasMa6Mu6−RasMu6He6
Colonies in soft agar *0 ± 0247 ± 221.3 ± 0.652 ± 20ND
Mice with tumors/mice injected0/44/40/44/44/4
Latency (wk) NG (>20)7NG (>19)52
  • Abbreviations: NG, no growth. ND, not determined.

  • * Average number and SD of colonies growing in soft agar from triplicate plates.

  • Latency was determined as the time taken before a palpable mass could be detected.