Table 1.

Cellular sensitivity to 17-AAG treatment

Cell lineIC50 (nmol/L 17-AAG)B-RAF status
Sk-Mel-28.7WT
SW62017.0WT
CHL18.2WT
Colo82915.4V600E
501Mel18.5V600E
A37520.0V600E
WM266.419.0V600D
NC-H16662.9G466V
  • NOTE: Cell proliferation was measured by sulforhodamine B staining in the presence of a range of 17-AAG concentrations.