Table 1.

CDC4 mutations detected in this study (A) and in that of Rajagopalan et al. (ref. 2; B)

(A)
CDC4 exonNucleotide changeAmino acid changeMutation typeLOHSpecimenSample IDPloidy (modal chromosome no.)MSIAPC mutationK-ras mutationp53 mutation
3C670TR224XNonsenseNoMetastasis3822/93MDiploid+
4C832TR278XNonsenseNoAdenoma13103/93PDiploid
4C832TR278XNonsenseNoCarcinoma452/94CAneuploid
4C832TR278XNonsenseNoCell lineC32Hypertriploid (74)776FS+LOHNone foundNone found
4C845AS282XNonsenseNoCarcinoma284AAneuploidNone foundNone foundNone found
6C1099TR367XNonsenseNoCarcinoma1644aAneuploidNone foundNone foundR273H
7C1177TR393XNonsenseNoCarcinoma1350DiploidR213X(C>T); 1411FSNone foundNone found
8C1393TR465CMissenseNoCarcinoma10593/90C+
8C1393TR465CMissenseNoAdenoma15935P*Aneuploid
8C1393TR465CMissenseNoCarcinoma307AneuploidR1114X(C>T)None foundNone found
8G1394AR465HMissenseNoMetastasis15935/93MAneuploid
9G1436AR479QMissenseNoCarcinoma13854/93CAneuploid
9G1436AR479QMissenseNoCarcinoma12829/93CDiploid+
9G1436AR479QMissenseNoAdenoma4624/93PDiploid
9C1513TR505CMissenseLOHCarcinoma8244/9/93C
9C1513TR505CMissenseNoCell lineLOVOHyperdiploid (49)+R1114X(C>T);1430FSG>A c13None found
9G1514CR505PMissenseNoCarcinoma17205/93CDiploid
10C1787TS596FMissenseLOHCarcinoma1494Diploid1413FSNone foundNone found
(B)
TumorCDC4 exonNucleotide changeAmino acid changeMutation type*LOH
13C418TQ220XNonsenseNo
23C430TR224XNonsenseNo
33C430TR224XNonsenseNo
44C592TR278XNonsenseNo
10C1505TS582LMissenseNo
54C592TR278XNonsenseNo
65C667TQ303XNonsenseNo
75A696CR312SMissenseNo
87C937TR393XNonsenseNo
10C1505TS582LMissenseNo
97C937TR393XMissenseNo
10C1505TS582LMissenseNo
107G950AG397DNonsenseLOH
118G1028TG423VMissenseLOH
128C1073TS438FMissenseNo
138G1098AW446XNonsenseNo
148C1153TR465CMissenseNo
158C1153TR465CMissenseNo
168C1153TR465CMissenseNo
178G1154AR465HMissenseNo
188C1153TR465CMissenseNo
199G1196AR479QMissenseNo
209G1196AR479QMissenseNo
219G1196AR479QMissenseNo
229G1196AR479QMissenseNo
239G1217AW486XNonsenseNo
249G1388AR543KMissenseNo
259A1394GY545CMissenseLOH
2610C1505TS582LMissenseNo
  • NOTE: Absence of data means not done.

  • * The types of some mutations have been corrected from those originally reported by Rajagopalan et al. (2) Supplementary Table 1.