Table 1.

Characteristics of TLR4 SNPs

IIPGA nameSNP nameNucleotide changeLocationrs no.Minor allele frequency, (controls)HWE P (controls)
TLR4_851SNP1A→G5′ UTRrs277015026.30.32
TLR4_1859SNP2G→A5′ UTRrs1153685838.50.25
TLR4_1893SNP3A→G5′ UTRrs647831735.30.18
TLR4_2032SNP4T→C5′ UTRrs1011625328.50.29
TLR4_2437SNP5A→G5′ UTRrs192791435.10.15
TLR4_2856SNP6T→C5′ UTRrs1075993216.20.10
TLR4_7764SNP7G→AIntronrs192791129.00.44
TLR4_9263SNP8C→AIntronrs1153687812.30.0001
TLR4_11547SNP9A→GIntronrs503071712.80.09
TLR4_11912SNP10G→TIntronrs214935634.10.02
TLR4_13015*SNP11A→GExonrs49867905.20.02
TLR4_15844*SNP12G→C3′ UTRrs1153688913.80.53
TLR4_16649SNP13G→C3′ UTRrs787378417.90.02
TLR4_17050SNP14T→C3′ UTRrs1153689118.00.06
TLR4_17723SNP15G→A3′ UTRrs115368975.40.03
TLR4_17923SNP16C→A3′ UTRrs153689814.80.26
  • NOTE: TLR4_13015 (SNP11) corresponds to the nonsynonymous SNP, 8552A/G, in the report of Zheng et al. (14). This nonsynonymous amino acid substitution, D299G, is in strong linkage disequilibrium with the nonsynonymous change, T399I, which was not selected in this study. TLR4_15844 (SNP12) corresponds to the prostate cancer risk SNP, 11381 G/C, in the report of Zheng et al. (14).