Table 1.

BMP4 and BMP7 expression in nevi, primary melanoma, and metastasis of malignant melanoma

Expression levelNevi (total = 11 sections)Primary melanoma (total = 5 sections)Metastasis of malignant melanoma (total = 4 sections)
BMP4
    No2
    Weak8
    Moderate14
    Strong5
BMP7
    No1
    Weak9
    Moderate1
    Strong54
  • NOTE: Immunohistochemistry analysis of nevi sections revealed no or only weak expression of BMP4 and BMP7. Primary melanomas showed strong expression for both proteins, whereas metastases of malignant melanoma showed moderate BMP4 expression and strong BMP7 expression.