Table 2.

Comparisons of radiation-induced transformation between MEFs of different genotypes versus wild-type MEFs

Atmhz/Mrad9wtAtmwt/Mrad9hzAtmhz/Mrad9hz
Relative transformation (2 Gy)1.911.453.10
t test (2 Gy)P = 0.03P = 0.31P = 0.0001
  • NOTE: Relative transformation is defined as the ratio of the number of transformed clones per surviving heterozygous cells relative to the number of transformed clones per surviving wild-type cells. The statistical significance of differences in transformation frequency between the various cells with heterozygous genotypes and wild-type cells was analyzed by Student's t test.