Table 1.

Differential gene expression in cells overexpressing wild-type or Y705F STAT3

Accession no.WTY705F
Fold changeGene name
A, gene expression profiles in hTERT-HME1 cells
14052842Human T cell–specific protein (RANTES) *
2106152018Neuropilin-1 soluble isoform 11 (NRP1)
2097831712Human Tis11d primary response gene* *
2195141711Angiopoietin-like 2 (ANGPTL2)
33814172.1Serine/threonine kinase 6
2065381362Muscle RAS oncogene (MRAS)* *
204760146.5Nuclear receptor subfamily D1 (NR1D1)
2028611115Period (PER1)
203765118.6Grancalcin (GCL)
2121251110Ran GTPase activating protein 1 (Ran GAP1)* *
2116079.27.5Epidermal growth factor receptor (EGFR)
2016418.65.7Bone marrow stromal cell antigen 2 (BST2)
2056818.66.1BCL2-related protein A1 (BCL2A1)* *
2007845.34.3Low density lipoprotein-related protein 1
2037104.34.0Inositol 1,4,5-triphosphate receptor 1 (ITPR1)
2071864.34.3Fetal Alzheimer antigen (FALZ)
2203704.04.3KIAA1453 protein (KIAA1453)
2101633.53.7Interferon stimulated T-cell α chemoattractant (I-TAC)
2099563.34.6Calciumcalmodulin-dependent protein kinase II β
2138072.76.9Met proto-oncogene* *
2061672.52.3Rho GTPase activating protein 6 (Rho GAP6) * *
2025082.3−2.5Synaptosomal-associated protein, 25kD (SNAP25)
202237−4.9−4.3Nicotinamide N-methyltransferase (NNMT)
202036−5.7−4.0Secreted apoptosis related protein 2 (SARP2)
B, gene expression profiles in MEFs
93099392.0GM-CSF
930992114Polo-like kinase 1* *
1010592037Necdin
1003091816Met proto-oncogene* *
100885152.1Interleukin 6
99435128.6Fibroblast growth factor 7
939431217Tis11d primary response gene
101019117.5Cathepsin C
93940117.5Paraoxonase 3
986039.210.4RAN GTPase activating protein 1* *
1029348.32.0Cell division cycle control protein 25C* *
1045278.14.0Rad51
938817.02.3TGN38B
971826.73.3Cyclin E2
991866.53.5Cyclin A2
1019376.57.9Cdc2*
1008855.92.0Serine/threonine kinase (nek2)
996325.03.3Mitotic checkpoint component Mad2
1600924.63.7Interferon β
926394.52.1Serine/threonine kinase 6* *
1605014.45.7Rabkinesin-6
1029634.32.0E2F-1
1601593.52.5Cyclin B1*
1001563.34.0CDC46
947613.33.7Small inducible cytokine A7
1003683.32.8Caspase9S
1022923.0−2.5GADD45 protein (gadd45) gene
983492.63.0IL-6 signal transducer (gp130)
957852.62.8RAB7 (member RAS oncogene family)
979912.52.5Ki-ras cellular oncogene
938702.52.8Braf transforming gene
1003022.53.7mafF
936132.12.8mSmad3
93456−4.03.25BMP-4
98924−8.6−16ART3
98406−294−22Cathepsin Z (ctsZ gene)
  • NOTE: The expression of 22,000 genes in human Affymetrix U133A arrays and 12,000 genes in mouse Affymetrix U74Av2 arrays was analyzed. Some of the induced genes were chosen to be shown here because of their roles in regulating the cell cycle or in tumorigenesis. Full list available upon request. In human Affymetrix arrays, gene expression in hTERT-HME1 cells infected with empty vector was taken as the baseline. In mouse Affymetrix arrays, gene expression in STAT3-null cells was taken as baseline.

  • * Expression of genes has been confirmed by the Northern or Western methods.