Table 1.

Multivariate-adjusted ORs and 95% CI for associations of daily intake of B vitamins with risk of breast cancer in the Long Island Breast Cancer Study Project, 1996-1997

Nutrient typeQuintiles of dietary intake
Q1 (lowest intake)Q2Q3Q4Q5P, trend *
Dietary folate
    Range (μg/d)≤159>159-216>216-279>279-356>356
    Cases/controls314/296276/297308/296265/297263/296
    OR (95% CI) 1.00 (referent)0.89 (0.70-1.13)1.00 (0.78-1.29)0.85 (0.65-1.11)0.85 (0.64-1.14)0.29
Total folate (diet + supplements)
    Range (μg/d)≤208>208-330>330-561>561-722>722
    Cases/controls309/300305/294256/295280/299276/294
    OR (95% CI) 1.00 (referent)1.03 (0.81-1.31)0.85 (0.67-1.08)0.93 (0.73-1.18)0.95 (0.74-1.22)0.43
Vitamin B1 (thiamin)
    Range (mg/d)≤0.72>0.72-0.95>0.95-1.16>1.16-1.48>1.48
    Cases/Controls344/307300/290259/292273/303250/290
    OR (95% CI) 1.00 (referent)0.87 (0.67-1.13)0.74 (0.56-0.99)0.72 (0.53-0.98)0.69 (0.49-0.96)0.02
Vitamin B2 (riboflavin)
    Range (mg/d)≤0.95>0.95-1.30>1.30-1.62>1.62-2.12>2.12
    Cases/Controls331/293296/302265/295271/296263/296
    OR (95% CI) 1.00 (referent)0.85 (0.66-1.09)0.78 (0.59-1.02)0.80 (0.59-1.07)0.76 (0.55-1.04)0.13
Vitamin B3 (niacin)
    Range (mg/d)≤9.8>9.8-12.9>12.9-15.7>15.7-19.9>19.9
    Cases/Controls337/296292/299252/293287/299258/295
    OR (95% CI) 1.00 (referent)0.85 (0.65-1.10)0.75 (0.56-1.00)0.85 (0.63-1.16)0.78 (0.56-1.09)0.24
Vitamin B6 (pyridoxine)
    Range (mg/d)≤0.84>0.84-1.15>1.15-1.42>1.42-1.84>1.84
    Cases/controls309/300321/297269/295275/300252/290
    OR (95% CI) 1.0 (referent)1.09 (0.85-1.40)0.92 (0.70-1.20)0.91 (0.68-1.21)0.87 (0.64-1.18)0.17
  • * P value for trend for categorical variables.

  • Adjusted for age, family history of breast cancer in first-degree relative, history of benign breast disease, educational attainment, body mass index at age 20, and kilocalories per day.