Table 2.

Multivariate-adjusted ORs and 95% CI stratified by supplement use for associations of daily intake of B vitamins with risk of breast cancer in the Long Island Breast Cancer Study Project, 1996-1997

Nutrient typeQuintiles of dietary intake
Q1 (low)Q2Q3Q4Q5P, trend *
Folate
    Supplement use = no
        Cases/Controls189/164142/154164/148125/13493/133
        OR (95% CI) 1.0 (referent)0.82 (0.59-1.16)0.98 (0.69-1.38)0.83 (0.57-1.23)0.61 (0.41-0.93)0.06
    Supplement use = yes
        Cases/controls125/132134/143144/148140/163170/163
        OR (95% CI) 1.0 (referent)0.99 (0.69-1.42)1.04 (0.71-1.51)0.91 (0.62-1.35)1.11 (0.73-1.67)0.75
Vitamin B1
    Supplement use = no
        Cases/controls193/157163/150125/137133/14899/141
        OR (95% CI) 1.0 (referent)0.81 (0.56-1.16)0.66 (0.44-1.00)0.62 (0.40-0.97)0.45 (0.28-0.74)0.002
    Supplement use = yes
        Cases/controls151/150137/140134/155140/155151/149
        OR (95% CI) 1.0 (referent)0.95 (0.66-1.37)0.83 (0.55-1.24)0.85 (0.55-1.31)0.96 (0.61-1.53)0.81
Vitamin B2
    Supplement use = no
        Cases/controls186/157161/154135/139118/143113/140
        OR (95% CI) 1.00 (referent)0.81 (0.57-1.15)0.77 (0.52-1.14)0.69 (0.45-1.04)0.62 (0.39-0.99)0.05
    Supplement use = yes
        Cases/controls145/136135/148130/156153/153150/156
        OR (95% CI) 1.0 (referent)0.82 (0.57-1.19)0.74 (0.49-1.10)0.88 (0.57-1.34)0.81 (0.51-1.28)0.60
Vitamin B3
    Supplement use = no
        Cases/controls187/147150/152121/138144/153111/143
        OR (95% CI) 1.0 (referent)0.73 (0.50-1.06)0.65 (0.43-0.99)0.69 (0.44-1.08)0.57 (0.35-0.94)0.05
    Supplement use = yes
        Cases/controls150/149142/147131/155143/146147/152
        OR (95% CI) 1.0 (referent)0.97 (0.68-1.40)0.84 (0.57-1.25)0.99 (0.65-1.51)0.98 (0.61-1.57)1.00
Vitamin B6
    Supplement use = no
        Cases/controls172/153184/159131/142119/146107/133
        OR (95% CI) 1.0 (referent)1.08 (0.76-1.52)0.81 (0.55-1.20)0.73 (0.48-1.10)0.70 (0.45-1.09)0.03
    Supplement use = yes
        Cases/controls137/147137/138138/153156/154145/157
        OR (95% CI) 1.0 (referent)1.11 (0.78-1.60)0.98 (0.67-1.44)1.11 (0.75-1.65)0.99 (0.65-1.52)0.96
  • * P value for trend for categorical variables.

  • Adjusted for age, family history of breast cancer in first-degree relative, history of benign breast disease, educational attainment, body mass index at age 20, and kilocalories per day.