Table 3.

ORs and 95% CI for MTHFR polymorphisms with risk of breast cancer in the Long Island Breast Cancer Study Project, 1996-1997

GenotypeNo. cases (%)No. controls (%)OR (95% CI) *OR (95% CI)
677C>T
    677CC398 (37.4)440 (39.9)1.0 (referent)1.0 (referent)
    677CT476 (44.8)509 (46.1)1.04 (0.87-1.26)1.05 (0.87-1.27)
    677TT189 (17.8)155 (14.0)1.34 (1.04-1.73)1.37 (1.06-1.78)
    P, trend 0.040.03
1298A>C
    1298AA558 (52.5)536 (48.6)1.0 (referent)1.0 (referent)
    1298AC417 (39.3)457 (41.4)0.88 (0.74-1.06)0.87 (0.72-1.05)
    1298CC87 (8.2)110 (10.0)0.77 (0.56-1.04)0.73 (0.53-1.00)
    P, trend0.050.03
Combined genotypes
    677CC-1298CC63 (6.0)69 (6.3)1.0 (referent)1.0 (referent)
    677CC-1298AC188 (17.8)198 (18.0)1.04 (0.70-1.55)1.09 (0.72-1.65)
    677CC-1298AA146 (13.8)172 (15.6)0.93 (0.62-1.40)0.97 (0.63-1.49)
    677CT-1298CC17 (1.6)32 (2.9)0.58 (0.30-1.15)0.60 (0.29-1.23)
    677CT-1298AC207 (19.6)218 (19.8)1.04 (0.70-1.54)1.09 (0.72-1.66)
    677CT-1298AA251 (23.7)259 (23.6)1.06 (0.72-1.56)1.12 (0.75-1.68)
    677TT-1298CC6 (0.6)9 (0.8)0.73 (0.25-2.17)0.82 (0.27-2.49)
    677TT-1298AC22 (2.1)41 (3.7)0.59 (0.32-1.09)0.63 (0.33-1.20)
    677TT-1298AA158 (14.9)102 (9.3)1.70 (1.11-2.59)1.82 (1.17-2.85)
  • * Adjusted for age.

  • Adjusted for age, family history of breast cancer in first-degree relative, history of benign breast disease, educational attainment, body mass index at age 20, and kilocalories per day.

  • P value for trend for categorical variables.