Table 1.

List of genes overexpressed in AGS cells following treatment with indomethacin

Gene nameAccession no.FunctionFold change
Claudin-1AF115546Tight junction2.00
Claudin-4AK026651Tight junction2.54
OccludinU49184Tight junction2.24
Tissue factor pathway inhibitor 2NM_006528Blood coagulation2.46
ZinedinAF212940Calmodulin binding protein2.01
Arginine-rich proteinAA582041Carcinogenicity2.00
Human urokinase-type plasminogen receptor, exon 7U09937Cell surface plasminogen activation2.81
Chromobox homologue 4 (Drosophila Pc class)AF013956Cellular memory system2.30
Human low-density lipoprotein receptor gene, exon 18L00352Cholesterol homeostasis3.43
Low-density lipoprotein receptor (familial hypercholesterolemia)NM_000527Cholesterol homeostasis2.75
Epithelial protein lost in neoplasm βAA594624Cytoskeleton2.58
Keratin 8AI978932Cytoskeleton2.37
Immediate early response 3AI022951Differentiation2.36
Prostate differentiation factorAB000584Differentiation2.00
Procollagen-prolineJ02783Disulfide isomerase/oxidoreductase2.50
Glucosidase β, acid (includes glucosylceramidase)AF023268Glucocerebrosidase2.01
Tumor necrosis factor--induced protein 6M31165Hyaluronan binding protein family2.14
BasiginX64364Immunoglobulin superfamily2.15
Solute carrier family 7M80244l-Amino acid transporter3.00
Cathepsin DM11233Lysosomal proteinase2.40
Pim-1 oncogeneM24779Protein kinase2.52
Cytochrome c oxidase subunit VIIIJ04823Respiratory2.90
3,4-Dihydroxy-l-phenylalanine decarboxylase (aromatic l-amino acid decarboxylase)M76180Synthesis of dopamine and serotonin2.27
CCAAT/enhancer binding protein βW93514Transcription factor4.76
Predicted using Genefinder, preliminary predictionCAB60892Tumor protein p532.18
ATPase, H+ transporting, lysosomal (vacuolar proton pump) 21 kDaAI567477Vacuolar proton pump2.39
Ribosomal protein S21BE221408Unknown2.34
Human genomic DNA, chromosome 22q11.2, BCRL2 regionAP000553Unknown2.23
Ubiquinol-cytochrome c reductase (6.4 kDa) subunitAW163002Unknown2.13
IFN-induced transmembrane protein 3 (1-8U)X57352Unknown2.10
Conserved hypothetical proteinAAF96700Unknown2.07
KIAA0316 gene productAB002314Unknown2.06
Sequence 100 from patent WO9951727AX015425Unknown2.03
Ribosomal protein S28AW161288Unknown2.03
  • NOTE: Fold changes in gene expression by indomethacin compared with untreated cells. Mean values from four independent hybridizations. AGS cells were treated with or without 0.3 mmol/L indomethacin for 4 hours and subjected to DNA microarray analysis.