Table 1.

HE4 protein expression in normal human tissues

Normal tissuesPositive/testedHistological description
Esophagus0/2
Stomach0/4
Gallbladder0/5
Duodenum0/6
Colon0/6
Pancreas0/4
Liver0/5
Spleen0/5
Lymph node0/7
Skeletal muscle0/4
Cardiac muscle0/4
Lung1/4Proximal respiratory epithelium
Trachea5/5Respiratory epithelium and minor salivary glands
Thyroid0/6
Kidney5/6Focal in a minority of tubules
Brain0/4
Breast4/5Predominantly in secretions with focal reactivity in a minority of ducts
Ovary0/7Negative in OSE; positive in metaplastic, ciliated CICs
Fallopian tubes10/10
Endometrium4/4
Cervix4/4Endocervical glands only
Epididymis5/5Strongest staining in duct of the epididymis, weaker staining in efferent ducts
Testes0/4
Prostate4/7Weak, focal glandular epithelial staining