Table 2.

Summary of immunohistochemical staining of ovarian carcinomas with HE4 antibodies

Intensity of immunostaining *
Histologic subtytpesStrong (% diffuse )Moderate (% diffuse)Weak (% diffuse)NegativeP
Papillary serous (n = 60)24 (100)32 (90)4 (75)0
Endometrioid (n = 16)12 (100)4 (100)000.014
Mucinous (n = 10)01 §090.001
Clear cell (n = 6)2 (100)1 (50)030.10
  • * All cases were independently reviewed and scored by four pathologists (R.D., C.P.C., W.R.W., J.L.H.).

  • Diffuse staining is defined as immunoreactivity over ≥75% of the tumor area.

  • Compares distribution of papillary serous immunostaining with endometriod, mucinous, and clear cell subtypes, using exact version of Kruskal-Wallis nonparametric test for singly ordered RxC contingency (Software: StatXact, version 6.1 2003, Cytel Software).

  • § Represents a high-grade mucinous tumor. HE4 immunoreactivity was present throughout, including stromal components.