Table 1.

Study population

TGFBR1 study population *TGFB1 study population
Cases (n = 611), n (%)Controls (n = 690), n (%)PCases (n = 658), n (%)Controls (n = 841), n (%)P
TGFBR1 genotype
    *9A/*9A515 (84.3)612 (88.7)0.03
    *9A/*6A92 (15.1)77 (11.2)
    *6A/*6A4 (0.6)1 (0.1)
TGFB1 genotype
    TT200 (30.4)240 (28.5)0.23
    TC339 (51.5)419 (49.9)
    CC119 (18.1)182 (21.6)
Age (y) §
    20-4089 (14.6)394 (57.1)<0.0197 (14.7)534 (63.5)<0.01
    41-50166 (27.2)82 (11.9)181 (27.5)84 (10.0)
    51-60168 (27.5)110 (15.9)178 (27.1)112 (13.3)
    61-70120 (19.6)69 (10.0)127 (19.3)75 (8.9)
    71+68 (11.1)35 (5.1)75 (11.4)36 (4.3)
    Mean (SD) §54.0 (12.7)55.3 (11.2)53.9 (12.9)55.4 (11.1)
Race
    White512 (83.8)541 (78.4)<0.01544 (82.7)649 (77.2)<0.01
    Black44 (7.2)43 (6.2)53 (8.1)51 (6.1)
    Hispanic25 (4.1)80 (11.6)27 9 (4.1)110 (13.1)
    Asian18 (3.0)22 (3.2)20 (3.0)26 (3.1)
    Unknown12 (1.9)4 (0.6)14 (2.1)5 (0.5)
  • * The exact age was not known for 360 controls in the lowest age category (20-40 years).

  • The exact age was not known for 500 controls in the lowest age category (20-40 years).

  • P for χ2 or Fisher's exact test (comparing proportions).

  • § Average age for controls was calculated based on those with exact age available.