Table 1.

Plasma pharmacokinetics of NU7441 following different routes of administration

VariableRoute of administration (dose)
i.v. (5 mg/kg)Oral (10 mg/kg)i.p. (10 mg/kg)
Cmax (μg/mL)1.6 *0.52.4
Tmax (min)5305
AUClast (μg/mL min)7649150
AUCinf (μg/mL min)7872152
T1/2 (min)4612753
CL (mL/kg/min)6514066
Bioavailability (%)10033100
  • NOTE: Cmax = concentration maximum. Tmax = time of Cmax. T1/2 = elimination half-life.

    Abbreviations: AUC, area under the curve; CL, clearance.

  • * Data are calculated from means obtained at 5,10,15, 30, 60, 90, 120, 180, 240, and 360 min after administration from three mice per time point.