Table 2.

Tissue to plasma concentration ratios in SW620 tumor-bearing nude mice

Time (min)NU7441 tissue to plasma ratio
TumorBrainKidneyLiverSpleen
150.38 *1.14.26.44.6
301.42.23.4113.2
600.443.23.65.43.2
901.5314198.7
2404.66.21.0519
  • * Data are means of three values obtained from three replicate mice per time point expressed as NU7441 concentration in the tissue divided by NU7441 in the plasma at each time point after i.p. injection of NU7441 at 10 mg/kg.