Table 1.

HDIs cause down-regulation of TNFR1 mRNA in a variety of human NSCLC cell lines

Cell lineNSCLC subtypeRelative expression of TNFR1 (% of untreated control ± SD)
10 μmol/L SAHA50 μmol/L SAHA2 μmol/L TSA4 μmol/L TSA
A-427Adenocarcinoma36 ± 621 ± 120 ± 325 ± 2
A549Adenocarcinoma29 ± 413 ± 212 ± 112 ± 2
NCI-H23Adenocarcinoma21 ± 17 ± 16 ± 17 ± 1
NCI-H1563Adenocarcinoma91 ± 529 ± 321 ± 226 ± 2
NCI-H1703Adenocarcinoma35 ± 115 ± 218 ± 217 ± 1
NCI-H460Large cell carcinoma24 ± 19 ± 16 ± 16 ± 1
NCI-H520Squamous cell carcinoma23 ± 19 ± 18 ± 07 ± 0
NCI-H2170Squamous cell carcinoma40 ± 210 ± 110 ± 19 ± 1
  • NOTE: NSCLC cell lines were treated with HDIs for 24 hours and expression of TNFR1 was assayed by TaqMan PCR.