Table 3.

Phosphorylated proteins in the skin of A-ZIP/F-1 mice relative to wild-type mice

Panel KPSS-1.3RatioPanel KPSS-11.0RatioPanel KPSS-12.0Ratio
JNK (SAPK)0.36Lyn (48)0.38Tau0.50
MEK3/60.45IR0.44eIF2a0.56
CDK1/20.50PKCb1/20.50Rad170.67
RSK1/30.60PKA/Ca/b0.57Pax2 (37)0.67
B23 (NPM)0.65PKCg0.75Pax2 (36)0.68
GSK3a0.71PKCh1.28Hsp270.69
p38a MAPK0.72PRK11.31Dok21.22
PKCa0.72FAK-Y3971.34NMDA Nr2B1.30
PKCd0.72PKCz/l1.35Cortactin1.43
Jun (41)1.20GRK21.36MARCKS1.49
Src1.24PKCe1.38Erk11.51
Erk21.41PKCb21.41Erk22.20
Erk11.45FAK-S8431.58Shc12.45
MEK1/21.46PRK21.61Adducin a2.48
Smad1/5/81.53PKCa1.79AcCoA carboxylase2.76
PKR (73)1.65Erk11.81PRAS402.99
STAT31.69PKCa/b21.84Cofilin 13.09
GSK3a1.97PKR (73)2.26eIF4G3.97
Adducin a2.24Erk22.59
PKBa (Akt1) [S473]3.43ErbB23.05
PKBa (Akt1) [T308]4.09FAK-Y7223.35
  • NOTE: Phosphoproteins were measured using the Kinexus phospho-antibody screening system. Approximately 87 phosphoproteins were detected. The difference between A-ZIP/F-1 and wild-type mice is expressed as a fold change ratio. If the ratio is higher than 1, the kinase activity is increased in the A-ZIP/F-1 mice relative to the wild-type mice; if the ratio is below 1, it indicates that it is decreased.