Table 1.

Characteristics of the study population for ASC/TMS1 methylation status by adenocarcinoma and squamous cell carcinoma histology (N = 134)
CharacteristicsAdenocarcinomaSquamous cell carcinoma
Unmethylated, n = 55Methylated, n = 26PUnmethylated, n = 45Methylated, n = 8P
n (%)n (%)n (%)n (%)
Region0.320.71
    United States19 (34.5)12 (46.2)26 (57.8)4 (50.0)
    Japan36 (65.5)14 (53.8)19 (42.2)4 (50.0)
Gender0.570.64
    Male27 (49.1)11 (42.3)37 (82.2)6 (75.0)
    Female28 (50.9)15 (57.7)8 (17.8)2 (25.0)
Age, median and interquartile range (y)68 (59-75)63 (57-68)0.0771 (63-75)66.5 (57-72)0.21
Age, categorical (y)0.090.16
    <6014 (25.5)11 (42.3)5 (11.1)3 (37.5)
    60-6917 (30.9)10 (38.5)12 (26.7)2 (25.0)
    70+24 (43.6)5 (19.2)28 (62.2)3 (37.5)
Histologically positive lymph nodes<0.0010.25
    Yes8 (14.6)15 (57.7)13 (28.9)4 (50.0)
    No47 (85.4)11 (42.3)32 (71.1)4 (50.0)
Pulmonary0.380.99
    Yes3 (5.5)3 (11.5)4 (8.9)0 (0.0)
    No52 (94.5)23 (88.5)41 (91.1)8 (100)
Pleural0.690.99
    Yes15 (27.3)6 (23.1)12 (26.7)2 (25.0)
    No40 (72.7)20 (76.9)33 (73.3)6 (75.0)
Lymphatic0.0010.11
    Yes15 (27.3)17 (65.4)14 (31.1)5 (62.5)
    No40 (72.7)9 (34.6)31 (68.9)3 (37.5)
Vascular0.610.99
    Yes12 (21.8)7 (26.9)14 (31.1)2 (25.0)
    No43 (78.2)19 (73.1)31 (68.9)6 (75.0)
Distribution of stage for ASC/TMS1 methylation status stratified by adenocarcinoma and squamous cell carcinoma histology (N = 134)
AdenocarcinomaSquamous cell carcinoma
Unmethylated, n = 55Methylated, n = 26PUnmethylated, n = 45Methylated, n = 8P
n (%)n (%)n (%)n (%)
Stage<0.001 *0.68 *
    I43 (86.0)7 (14.0)28 (87.5)4 (12.5)
    II2 (22.2)7 (77.8)<0.001 6 (75.0)2 (25.0)0.58
    III9 (47.4)10 (52.6)0.002 11 (84.6)2 (15.4)0.96
    IV1 (33.3)2 (66.7)0.07 §0 (0.0)0 (0.0)
  • NOTE: Percentages are presented by row.

  • * P value, determined by χ2 test or Fisher's exact test, comparing all advanced stages to stage I.

  • Comparison between stage I and stage II only.

  • Comparison between stage I and stage III only.

  • § Comparison between stage I and stage IV only.