Table 2.

Genes stimulated by at least 2-fold after 2, 4, and 8 hours of DHT treatment

Symbol2 h4 h8 h24 hGene description
C1orf1167.38.410.15.9Chromosome 1 open reading frame 116 (SARG)
SGK4.978.10.8Serum/glucocorticoid-regulated kinase
TMPRSS22.16.17.75.5Transmembrane protease, serine 2
TMEPAI3.94.563.4Transmembrane, prostate androgen induced (STAG1)
NKX3.12.84.34.43.6NK3 transcription factor related, locus 1
C1orf212.04.32.80.9Proliferation-inducing protein 13
C16orf33.94.13.84.4Chromosome 16 open reading frame 3
SNAI22.645.71.4Snail homologue 2 (SLUG)
CHI3L12.13.93.11.3Chitinase 3-like 1 (cartilage glycoprotein-39)
SLCO1B12.03.72.30.2Solute carrier organic anion transporter family, member 1B1
HIST1H3J2.83.64.72.8Histone 1, H3j
GPR203.33.52.91.3G protein-coupled receptor 20
SULT2A12.23.22.41.2Sulfotransferase, cytosolic, 2A, DHEA-preferring, member 1
CASP82.13.12.32.8Caspase-8, apoptosis-related cysteine protease (FLICE)
ADRB32.432.81.2Adrenergic, β3, receptor
STAT5A2.52.92.92Signal transducer and activator of transcription 5A
DIO222.92.61.1Deiodinase, iodothyronine, type II, transcript variant 1
ASCL12.12.82.21.2Achaete-scute complex-like 1 (Drosophila)
PTGER42.12.72.71.8Prostaglandin E receptor 4 (subtype EP4)
DPP42.32.62.41.6Dipeptidylpeptidase 4 (CD26)
PMAIP12.32.521.5PMA-induced protein 1 (APR, NOXA)
SLC1A32.92.42.13Glial high-affinity glutamate transporter (EEAT1)
PGDS2.32.22.51.7Prostaglandin D2 synthase, hematopoietic
CCL162.32.120.9Chemokine (C-C motif) ligand 16
ROM122.12.11.8Retinal outer segment membrane protein 1
KPNA13.423.42.7Karyopherin α1 (importin α5)
DNCLI22.722.50.6Dynein, cytoplasmic, light intermediate polypeptide 2
NFKBIA2.622.21Nuclear factor-κB inhibitor, α
GRWD12.322.53.7Glutamate-rich WD repeat containing 1
RAB3B2.2222.9RAB3B, member RAS oncogene family
STARD82.1221.7START domain containing 8
  • NOTE: Some highly DHT-stimulated genes, such as PSA, are not included because their induction was <2-fold at 2 hours (PSA was induced 1.9-fold at 2 hours but strongly induced at later times).