Table 2.

Genes stimulated by at least 2-fold after 2, 4, and 8 hours of DHT treatment

Symbol2 h4 h8 h24 hGene description
C1orf1167.38.410.15.9Chromosome 1 open reading frame 116 (SARG)
SGK4.978.10.8Serum/glucocorticoid-regulated kinase
TMPRSS22. protease, serine 2
TMEPAI3.94.563.4Transmembrane, prostate androgen induced (STAG1)
NKX3. transcription factor related, locus 1
C1orf212. protein 13
C16orf33. 16 open reading frame 3
SNAI22.645.71.4Snail homologue 2 (SLUG)
CHI3L12. 3-like 1 (cartilage glycoprotein-39)
SLCO1B12. carrier organic anion transporter family, member 1B1
HIST1H3J2. 1, H3j
GPR203. protein-coupled receptor 20
SULT2A12., cytosolic, 2A, DHEA-preferring, member 1
CASP82., apoptosis-related cysteine protease (FLICE)
ADRB32.432.81.2Adrenergic, β3, receptor
STAT5A2.52.92.92Signal transducer and activator of transcription 5A
DIO222.92.61.1Deiodinase, iodothyronine, type II, transcript variant 1
ASCL12. complex-like 1 (Drosophila)
PTGER42. E receptor 4 (subtype EP4)
DPP42. 4 (CD26)
PMAIP12.32.521.5PMA-induced protein 1 (APR, NOXA)
SLC1A32.92.42.13Glial high-affinity glutamate transporter (EEAT1)
PGDS2. D2 synthase, hematopoietic
CCL162.32.120.9Chemokine (C-C motif) ligand 16
ROM122.12.11.8Retinal outer segment membrane protein 1
KPNA13.423.42.7Karyopherin α1 (importin α5)
DNCLI22.722.50.6Dynein, cytoplasmic, light intermediate polypeptide 2
NFKBIA2.622.21Nuclear factor-κB inhibitor, α
GRWD12.322.53.7Glutamate-rich WD repeat containing 1
RAB3B2.2222.9RAB3B, member RAS oncogene family
STARD82.1221.7START domain containing 8
  • NOTE: Some highly DHT-stimulated genes, such as PSA, are not included because their induction was <2-fold at 2 hours (PSA was induced 1.9-fold at 2 hours but strongly induced at later times).