Table 2.

Percentage of women with cytologic abnormalities by qualitative viral load

Qualitative viral load (PCR signal strength index) *
HPV type/group/speciesLow (1)Moderate (2-3)High (4-5)Total NPtrend
N% Abnormal N% AbnormalN% Abnormal
All single infections20313.340318.161633.01,222<0.0001
α10HPV6616.770.01030.0230.4
HPV11250.030.0050.2
HPV7401100.001
HPV4210.0020.03
HPV550425.004
α8HPV4020.02100.0040.05
α1HPV3240.030.030.010
α13HPV5430.01822.210.0220.6
α9HPV52 §40.01520.02020.0390.5
HPV6703100.0250.050.2
HPV3320.0633.31533.3230.5
HPV5890.01618.84544.4700.004
HPV16220.04219.19256.5156<0.0001
HPV3140.01816.72437.5460.05
HPV35333.32100.0742.9121.0
α11HPV73 333.310.0580.090.2
HPV3410.0001
HPV64010.001
α7HPV5920.0580.020.091.0
HPV181020.01030.01936.8390.4
HPV45333.320.0119.1160.3
HPV701811.12711.14035.0850.02
HPV39450.01216.71464.3300.2
HPV681100.0425.0837.5130.5
HPV8550.060.0156.7260.4
α5HPV26 10.020.0250.050.2
HPV511625.02119.13545.7720.08
HPV82 20.010.0333.360.3
HPV690010.01
α6HPV531136.41612.54719.2740.4
HPV5610.01127.31566.7270.03
HPV6610.0933.3862.5180.1
α15HPV71214.83810.55918.61180.09
α3HPV61238.7397.7390.01010.1
HPV7230.030.0425.0100.3
HPV62250.01811.13417.7540.8
HPV81250.0911.11526.7261.0
HPV83714.31723.5140.0380.2
HPV890425.004
HPV84425.0714.3560.0160.2
α1/α8/α10/α131811.13821.11618.8720.5
α9/α11484.210423.121046.7362<0.0001
α9/α11 (HPV16-)267.76225.811839.02060.001
α74318.66619.710932.12180.05
α5/α63225.06020.011137.82030.04
α3/α156211.313511.917014.73670.4
All carcinogenic8213.417323.731545.7570<0.0001
Carcinogenic (HPV16−)6018.313125.222341.3414<0.0001
Noncarcinogenic12113.223013.930119.66520.06
  • Abbreviation: Total N, sum of frequencies.

  • * PCR signal strength was originally a five-level variable collapsed into a three-level variable. The “1” indicates the weakest response; “2 to 3” indicates an intermediate response; and “4 to 5” indicates the strongest response. PCR signal strength for individual HPV types, HPV groups, and species were characterized using HPV type-specific PCR probes.

  • Ptrend indicates a two-sided trend test; bold Ps suggest significance at the 95% confidence level.

  • Abnormal includes women with atypical squamous cells of undetermined significance or worse cytologies.

  • § Bold indicates the HPV type is one of the 14 HPV types we categorized as carcinogenic.

  • Categorized as a possibly carcinogenic HPV type.