Table 2.

Penetration of anticancer drugs through MCLs derived from each cell line and through the coated Teflon membrane alone at 6 hours

Cell lineDoxorubicin5-FluorouracilPaclitaxelMethotrexate
Ea12.3 ± 1.012.1 ± 0.618.8 ± 2.15.78 ± 0.02
E1114.1 ± 3.514.8 ± 3.9
Ra55.1 ± 3.232.3 ± 7.145.4 ± 4.633.2 ± 3.0
1R135.8 ± 4.546.9 ± 1.9
Cell-free84.1 ± 5.480.3 ± 8.558.4 ± 1.645.1 ± 8.0
  • NOTE: Percent drug penetration is obtained from the ratio of the drug concentration in compartment 2 (at 6 hours) to drug concentration at equilibrium ± SD. Data represent results from three to five experiments. Penetration of paclitaxel and methotrexate was not studied in MCLs derived from E11 and 1R1 cell lines.