Table 1.

Selected processes overrepresented by the polysome-bound mRNAs affected by radiation

Overrepresented categoriesU87SF126SF539Astrocyte
GOstat scoreNo. genesGOstat scoreNo. genesGOstat scoreNo. genesGOstat scoreNo. genes
Genes with increased activity
    Cell cycle7.00e−03511.32e−09606.50e−11471.64e−0467
        Regulation of cell cycle3.00e−03342.23e−08391.27e−09315.86e−0749
    Transcription regulator activity
        Transcription factor binding6.92e−04208.87e−02171.00e−04183.64e−0634
        Transcription cofactor activity1.82e−04191.28e−03153.30e−0631
        RNA polymerase II transcription factor1.39e−03167.12e−02141.05e−02137.03e−0424
    Nucleotide metabolism4.32e−051644.07e−031812.65e−031271.36e−05281
        Transcription from RNA polymerase II3.74e−09365.99e−06354.99e−05254.99e−0851
    RNA metabolism
        RNA processing9.96e−03227.10e−03251.30e−03202.84e−0642
        mRNA metabolism5.34e−04184.38e−06231.76e−06184.54e−0833
            mRNA processing1.10e−03164.83e−06213.81e−04161.86e−0628
Genes with decreased activity
    Monosaccharide catabolism1.16e−0396.51e−0299.99e−04134.80e−0212
        Glycolosis2.01e−0392.05e−03113.26e−0211
  • NOTE: The polysome-bound mRNAs whose levels were modified by radiation by ≥2-fold were subjected to GOstat analysis. The categories were selected from the Gene Ontology pathways under biological process that were statistically overrepresented. The GOstat score refers to statistical significance (P).