Table 2.

Calculated doubling time for transferred cells and B16 tumor cells

Treatment group or tumord1-3d3-5
pmel-134.8N/A *
pmel-1/FP-hgp1009.842.7
pmel-1/FP-β-gal/IL-214.724.4
pmel-1/FP-hgp100/IL-25.312.7
B16.F10 24.9
  • NOTE: Calculated doubling time of transferred pmel-1 T cells or B16 tumor cells during the expansion phase. Values represent average rate of expansion as expressed by hours per single division. Doubling time = 48 hours / log2 (fold population or volume increase).

  • * Net decrease in population. Calculation of doubling time was not applicable.

  • B16.F10 value represented doubling time (hours per single division) of B16 melanoma cells growing in naive mice over a 48-hour period of optimal growth (days 12-14).