Clinical characteristics, histopathology, and PET-findings in indolent and aggressive lymphoma
| A. Correlation of histopathology, FLT/FDG uptake, and proliferation in indolent lymphoma | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Patient no. | Histology | Age | Clinical stage | Lesions FLT-PET | Lesions routine staging | Mean FLT-SUV | Mean FDG-SUV | Max FLT-SUV | Max FDG-SUV | Ki-67 index * |
| 2 | Follicular lymphoma grade I | 60 | IV A | 79 | 79 | 2.1 | 6.3 | 3.6 | 10.2 | 4 |
| 5 | Extramedullary plasmacytoma | 67 | I A | 3 | 3 | 1.3 | 2.1 | 1.8 | 2.8 | n/a |
| 6 | Lymphoplasmocytic lymphoma | 44 | IV A | 8 | 3 | 2.1 | 1.4 | 3.7 | 1.8 | n/a |
| 7 | Follicular lymphoma grade I | 57 | IV B Rel. | 53 | 57 | 4.5 | 3.9 | 8.1 | 6.1 | n/a |
| 9 | Follicular lymphoma grade II | 70 | IV A | 5 | 5 | 2.9 | n/a | 4.6 | n/a | 50 |
| 15 | Follicular lymphoma NOS | 38 | IV B Rel. | 51 | 52 | 2.6 | 4.5 | 4.2 | 6.5 | n/a |
| 17 | Follicular lymphoma grade I | 53 | III A | 14 | 14 | 1.5 | 3.2 | 2.7 | 5.1 | 1 |
| 21 | Follicular lymphoma grade I | 48 | II A E Rel. | 3 | 2 | 2.7 | 3.1 | 4.2 | 3.9 | 5 |
| 25 | Follicular lymphoma grade I | 37 | III B | 29 | 15 | 2.8 | n/a | 5.1 | n/a | n/a |
| 28 | Follicular lymphoma grade I | 53 | II A | 3 | 3 | 1.9 | n/a | 3.2 | n/a | 20 |
| 31 | Extranodal marginal zone lymphoma (MALT type) | 58 | I E | 1 | 1 | 1.2 | 3.2 | 1.3 | 3.9 | 1 |
| B. Correlation of histopathology, FLT/FDG uptake, and proliferation in aggressive lymphoma | ||||||||||
| 1 | Diffuse large B-cell lymphoma | 70 | IV | 33 | 13 | 5.5 | 3.1 | 10.3 | 4.7 | 80 |
| 3 | Diffuse large B-cell lymphoma (anaplastic variant) | 44 | IV | 1 | 1 | 4.1 | 6.6 | 5.6 | 10.5 | 80 |
| 8 | Diffuse large B-cell lymphoma | 64 | IV B | 6 | 6 | 4.8 | 3.6 | 5.3 | 5.5 | 80 |
| 10 | Diffuse large B-cell lymphoma (mediastinum) | 49 | III B Rel. | 3 | 2 | 4.7 | n/a | 6.6 | n/a | 85 |
| 11 | Diffuse large B-cell lymphoma | 43 | IV B Rel. | 5 | 5 | 3.2 | 3.1 | 5.6 | 4.0 | n/a |
| 12 | Diffuse large B-cell lymphoma (anaplastic variant) | 39 | IV B | 2 | 2 | 9.2 | n/a | 12.3 | n/a | n/a |
| 13 | Diffuse large B-cell lymphoma | 53 | III A Rel. | 2 | 2 | 5.3 | n/a | 8.7 | n/a | 80 |
| 14 | Diffuse large B-cell lymphoma | 61 | III E Rel. | 33 | 25 | 5.8 | n/a | 10.4 | n/a | 95 |
| 16 | Diffuse large B-cell lymphoma | 56 | IV B | 11 | 3 | 5.7 | 2.0 | 9.7 | 3.2 | 48 |
| 18 | Diffuse large B-cell lymphoma | 46 | I A E | 1 | 1 | 4.4 | 5.2 | 5.9 | 7.8 | n/a |
| 19 | Diffuse large B-cell lymphoma (centroblastic variant) | 39 | IV A E | 4 | 3 | 8.5 | 15.9 | 17.0 | 21.2 | n/a |
| 20 | Diffuse large B-cell lymphoma | 35 | IV B | 3 | 5 | 3.7 | 13.2 | 5.2 | 22.5 | n/a |
| 22 | Diffuse large B-cell lymphoma | 66 | II E B Rel. | 59 | 54 | 4.8 | 8.5 | 8.7 | 13.8 | 100 |
| 23 | Diffuse large B-cell lymphoma (anaplastic variant) | 38 | III B | 17 | 10 | 5.8 | 6.2 | 9.5 | 8.3 | 90 |
| 24 | Diffuse large B-cell lymphoma (T-cell rich variant) | 58 | IV B | 6 | 6 | 6.4 | n/a | 10.9 | n/a | n/a |
| 26 | Diffuse large B-cell lymphoma (anaplastic variant) | 38 | I A | 7 | 3 | 8.3 | n/a | 14.3 | n/a | 90 |
| 29 | Diffuse large B-cell lymphoma | 56 | I E Rel. | 1 | 1 | 3.5 | n/a | 3.7 | n/a | n/a |
| 30 | Diffuse large B-cell lymphoma (T-cell rich variant) | 64 | IV A E | 9 | 8 | 3.4 | n/a | 3.7 | n/a | 80 |
| 32 | Diffuse large B-cell lymphoma (anaplastic variant) | 82 | IV A | 15 | 12 | 8.8 | n/a | 9.4 | n/a | 90 |
| 33 | Diffuse large B-cell lymphoma (anaplastic variant) | 50 | I B | 4 | 4 | 8.0 | n/a | 9.1 | n/a | 80 |
| 34 | Diffuse large B-cell lymphoma (NOS) | 63 | IV E | 12 | 12 | 5.2 | 2.1 | 6.0 | 2.4 | n/a |
Abbreviations: Max, maximum; Rel., relapse.
↵* Number of Ki-67-labeled nuclei per total number of nuclei.