Table 2.

Site-specific urogenital system tumors induced by transplacental arsenic exposure together with postnatal diethylstilbestrol or tamoxifen treatment in female CD1 mice; ovary, oviduct, uterus, cervix, and vagina

Tumor site and typeGroup (n)
Control (33)Arsenic alone (34)DES alone (33)TAM alone (35)Arsenic + DES (33)Arsenic + TAM (35)
Ovary
    Adenoma0 (0%)4 (12%)2 (6%)1 (3%)6 (18%) *1 (3%)
    Carcinoma0 (0%)0 (0%)0 (0%)0 (0%)1 (3%)2 (6%)
    Total epithelial tumors0 (0%)4 (12%)2 (6%)1 (3%)7 (21%) *3 (9%)
    Hemangioma0 (0%)3 (9%)0 (0%)0 (0%)2 (6%)2 (6%)
    Total tumors any type0 (0%)7 (21%) *2 (6%)1 (3%)9 (26%) *, 5 (14%) *
Oviduct
    Hyperplasia5 (15%)27 (79%) *24 (73%) *30 (85%) *26 (79%) *25 (71%) *
    Adenoma0 (0%)0 (0%)1 (3%)1 (3%)2 (6%)3 (9%)
Uterus
    Adenoma0 (0%)3 (9%)0 (0%)0 (0%)0 (0%)0 (0%)
    Carcinoma0 (0%)2 (6%)0 (0%)2 (6%)7 (21%) *, 2 (6%)
    Total epithelial tumors0 (0%)5 (15%) *0 (0%)2 (6%)7 (21%) *2 (6%)
    Total tumors any type0 (0%)7 (21%) *0 (0%)2 (6%)7 (21) *, 2 (6%)
Cervix
    Carcinoma0 (0%)0 (0%)6 (18%) *, 0 (0%)8 (24%) *, 0 (0%)
    Total tumors any type0 (0%)0 (0%)6 (18%) *, 0 (0%)9 (27%) *, 0 (0%)
Vagina
    Carcinoma0 (0%)0 (0%)1 (3%)0 (0%)5 (15%) *, 0 (0%)
  • NOTE: See Table 1 for details. There were no adenoma of the cervix or vagina and no carcinoma of the oviduct. Total tumors any type (both epithelial and meschymal) includes a leiomyosarcoma and a hemangiosarcoma of the uterus in the arsenic alone group and a leiomyosarcoma of the cervix also in the arsenic alone group. The ovarian carcinoma in the arsenic + diethylstilbestrol group had metastasized to the liver.

  • * Significantly different (P < 0.05) from control.

  • Significantly different (P < 0.05) from diethylstilbestrol alone.

  • Significantly different (P < 0.05) from arsenic alone.