Table 1.

The rates of alterations of each gene in adenocarcinoma of the lung

AlterationTotalSmoking status
Never (n = 78)Light (n = 26)Heavy (n = 60)
Somatic mutation
    EGFR74 (45%)52 (66.7%)11 (42.3%)11 (18.3%)
    K-RAS16 (10%)3 (3.8%)2 (7.7%)11 (18.3%)
Aberrant methylation
    p16INK4a31 (18.9%)7 (9.0%)7 (26.9%)17 (28.3%)
    RASSF1A53 (32.3%)19 (24.4%)8 (30.8%)26 (43.3%)
    APC69 (42.1%)25 (32.1%)12 (46.2%)32 (53.3%)
    RARβ60 (36.6%)32 (41.0%)10 (38.5%)18 (30.0%)
    CDH1348 (29.3%)18 (23.1%)10 (38.5%)20 (33.3%)
Methylation index1.61.31.81.9
  • NOTE: The methylation index is defined as the total number of genes methylated in samples. The described value indicates the average of the methylation index in each group.