Table 1.

Characterization of anti-HGF antibodies

Antibody identificationka (1/Ms)kd (1/s)KD (mol/L)Ligand-receptor binding *c-Met phosphorylation in PC3 cells *HUVEC proliferation *U-87 MG proliferation/survival *
2.4.42.7 × 1052.7 × 10−59.9 × 10−115.11.2132
2.12.11.3 × 1052.8 × 10−52.2 × 10−102.10.4912956
1.29.16.2 × 1044.8 × 10−57.9 × 10−103.21.22122
1.75.13.6 × 1042.8 × 10−57.8 × 10−101.10.34168290
1.74.11.3 × 1054.7 × 10−53.6 × 10−103.71.33557
  • * IC50 values (nmol/L) were calculated from dose-response curves presented in Figs. 1, 3 and 4 (Materials and Methods).