Table 2.

Hsp72 inhibition by NZ28 and emunin

Cell lineStressStress conditionsHsp72 inhibition, by NZ28 (2 μmol/L), %Hsp72 inhibition, by emunin (10 μmol/L), %
CHOHeat Shock45°C, 10 min9995
MM.1s45°C, 4 min10090
PC-345°C, 20 min8580
MM.1sProteasome InhibitorVelcade, 5 nmol/L10095
PC-3MG132, 1 μmol/L9080
MEFVelcade, 10 nmol/L100
MM.1sHSP90 InhibitorRadicicol, 0.8 μmol/L9090
PC-317-AAG, 2 μmol/L7060
MEFRadicicol, 0.2 μmol/L100