Table 3.

Modulation of iNOS and COX-2 activities in the esophagus of NMBA-treated rats by BRB at 25 weeks

DietPreneoplasiaPapilloma
iNOS (mean ± SE) *COX-2 (mean ± SE) iNOS (mean ± SE)COX-2 (mean ± SE)
Control4.40 ± 0.523.05 ± 0.597.66 ± 1.6518.10 ± 4.40
5% BRB4.17 ± 0.831.22 ± 0.13 4.04 ± 1.246.98 ± 1.68
  • * iNOS activity is expressed as μmol/L nitrite.

  • COX-2 activity is expressed as μg/mg protein.

  • Significantly lower than rats fed control diets (P < 0.05).