Table 2.

Effects of DNMT inhibitors in various assays

Cytotoxicity *Apoptosis induction Genotoxicity Genomic demethylationTIMP-3 demethylationTIMP-3 reactivationSssI inhibition
5-aza-CR++++++
5-aza-CdR++++++
zebularine+++
procaine+
EGCG+++NA
RG108++
  • Abbreviation: NA, not applicable.

  • * Cytotoxicity was determined by colony formation assays.

  • Apoptosis induction was determined by Annexin V staining.

  • Genotoxicity was determined by micronuclei formation assays.