Table 1.

Pathology evaluation of overall macrometastases and micrometastases in lungs and bones

GroupMacroscopicallyLungBone
Normal saline and vehicle (0.1% HPMC)
    Mouse 1Extensive tumor involvement: ascites, liver, mesentery, lung, axillary lymph nodesExtensive tumor involvementTumor in soft tissue. No tumor in bone marrow
    Mouse 2Axillary lymph nodesRare tumor cells seenNo tumor seen
    Mouse 3No tumor seenRare tumor cells seenNo tumor seen
    Mouse 4Extensive tumor involvement: ascites, mesentery, axillary lymph nodesOccasional tumor foci seenTumor in soft tissue. No tumor in bone marrow
    Mouse 5n/an/an/a
UFT 15 mg/kg and normal saline
    Mouse 1No tumor seenNo tumor seenNo tumor seen
    Mouse 2No tumor seenNo tumor seenNo tumor seen
    Mouse 3No tumor seenNo tumor seenNo tumor seen
    Mouse 4No tumor seenNo tumor seenNo tumor seen
    Mouse 5No tumor seenNo tumor seenNo tumor seen
Cyclophosphamide 20 mg/kg and vehicle (0.1% HPMC)
    Mouse 1No tumor seenNo tumor seenNo tumor seen
    Mouse 2No tumor seenNo tumor seenNo tumor seen
    Mouse 3No tumor seenNo tumor seenNo tumor seen
    Mouse 4No tumor seenNo tumor seenNo tumor seen
    Mouse 5No tumor seenNo tumor seenNo tumor seen