Table 1.

Estrogen depletion reduces but does not completely inhibit tumor formation

GenotypeAge (wk)TreatmentNo. miceNo. mice with lesions (%)No. lesions per mouse (mean ± SD)Size of lesion (mm2)Range of size (mm2)Ki-67 expression (%)
+/−32Ovariectomy98 (90)8.20 ± 10.270.13 ± 0.130.01→0.9651.6 ± 36.84
+/−32Oil99 (100)18.56 ± 8.570.22 ± 0.120.04→0.7578.12 ± 7.34
+/+32Ovariectomy900008.49 ± 3.98
+/+32Oil4000069.95 ± 25.69