Table 2.

Diethylstilbestrol treatment reduces ERα levels and completely inhibits uterine hyperplasia

ControlDES *
Wild typePten+/−Wild typePten+/−
Uterus weight/body weight (g)0.378 ± 0.07 1.993 ± 1.04 , 0.649 ± 0.160.692 ± 0.23
ERα relative expression11.0590.1090.347
  • * Uterus weight in diethylstilbestrol-treated includes the weight of the cervico-vaginal tract, which is markedly thickened as a result of the treatment.

  • P < 0.001.

  • P < 0.003.