Table 1.

Relative protein levels of different IAPs and Smac in thyroid cancer cells treated for 48 hours with the indicated chemotherapeutic drugs

DrugBC-PAPONCO-DG1FTC-133WROKAT-4SW-17368305-C
CDDP1.4 ± 0.35 *0.8 ± 0.31.1 ± 0.481.5 ± 0.27 *1.3 ± 0.19 *2.7 ± 0.58 1.3 ± 0.24 *
DOX1.3 ± 0.19 *1.2 ± 0.180.8 ± 0.560.9 ± 0.560.9 ± 0.521.8 ± 0.6 *1.3 ± 0.11 *c-IAP1
TAX1.9 ± 0.47 *0.6 ± 0.261.8 ± 0.47 *1.3 ± 0.443.4 ± 0.17 1.5 ± 0.27 *1.7 ± 0.3
CDDP2.2 ± 0.28 1.4 ± 0.530.5 ± 0.050.8 ± 0.320.8 ± 0.192.7 ± 0.93 *1.4 ± 0.05
DOX1.5 ± 0.471.4 ± 0.15 0.4 ± 0.130.9 ± 0.200.8 ± 0.082.3 ± 1.741.3 ± 0.3 c-IAP2
TAX1.5 ± 0.12 1.3 ± 0.291.0 ± 0.260.5 ± 0.141.7 ± 0.25 *1.2 ± 0.61.0 ± 0.1
CDDP0.9 ± 0.041.4 ± 0.05 2.1 ± 0.28 0.8 ± 0.492.1 ± 0.67 *1.7 ± 0.56 *1.4 ± 0.3 *
DOX3.1 ± 0.24 1.8 ± 0.852.7 ± 0.46 3.6 ± 0.51 2.1 ± 0.72 *1.7 ± 0.45 *1.8 ± 0.28 Surv
TAX6.4 ± 0.6 1.9 ± 0.65 *0.7 ± 0.320.8 ± 0.532.7 ± 0.09 1.7 ± 1.081.9 ± 0.73 *
CDDP1.4 ± 0.08 1.9 ± 0.571.2 ± 1.270.8 ± 0.260.8 ± 0.340.2 ± 0.371.8 ± 0.63 *
DOX6.0 ± 1.67 1.2 ± 0.322.1 ± 0.81 *0.7 ± 0.18 *0.8 ± 0.391.8 ± 0.54 *0.3 ± 0.07XIAP
TAX3.2 ± 1.3 *0.9 ± 0.050.9 ± 0.331.3 ± 0.451.2 ± 0.791.9 ± 0.53 *0.5 ± 0.32
CDDP1.1 ± 0.50.8 ± 0.471.5 ± 0.210.8 ± 0.1 *0.7 ± 0.481.8 ± 0.060.5 ± 0.03
DOX1.6 ± 0.371.0 ± 0.020.6 ± 0.02 0.9 ± 0.120.8 ± 0.141.7 ± 0.291.2 ± 0.18Smac
TAX0.5 ± 0.28 0.6 ± 0.15 *0.6 ± 0.07 1.0 ± 0.40.6 ± 0.350.5 ± 0.380.6 ± 0.04
  • NOTE: Statistical analysis indicates significance of increases in IAPs expression or reduction of Smac. Mean ± SD of three independent experiments with expression in untreated cells = 1.

  • * P < 0.05.

  • P < 0.01.

  • P < 0.001.