Table 1.

Effect of atorvastatin, celecoxib, and aspirin given individually and in combination on apoptotic and proliferatic indices in azoxymethane-induced colonic adenocarcinomas

Group no.TreatmentApoptotic index (%)PProliferative index (%)P
1Control4.15 ± 0.85 *54.44 ± 5.78
2Atorvastatin, 150 ppm8.23 ± 1.43 (98%) <0.0537.28 ± 4.29 (32%) <0.010
3Celecoxib, 600 ppm11.00 ± 2.30 (165%) <0.0233.81 ± 3.30 (38%) <0.002
4Aspirin, 400 ppm13.83 ± 0.31 (233%) <0.00137.26 ± 4.79 (32%) <0.01
5Atorvastatin, 100 ppm + celecoxib, 300 ppm12.97 ± 1.62 (212%) <0.00341.61 ± 1.52 (24%) <0.02
6Atorvastatin, 100 ppm + aspirin, 200 ppm10.06 ± 1.80 (142%) <0.0141.90 ± 3.26 (24%) <0.05
  • * Mean ± SE.

  • % Increase compared with those fed the control diet.

  • % Decrease compared with those fed the control diet.