Table 2.

Loci of homozygous deletion (log 2 ratio < −2.0) detected in NSCLC cell lines by array-CGH analysis using MCG Whole Genome Array-4500

No.BACLocus *Cell line (total 20)Possible candidate gene No. known genes
Chromosome bandPositionnName
1RP11-178M151p36.21chr1:13,731,635-13,731,966111-18PRDM22
2RP11-79M246p25chr6:1,754,013-1,926,7811KNS-62GMDS1
3RP11-31F199p24.3chr9:537,217-682,1431LC-1 sqANKRD157
RP11-143M159p24.3chr9:812,146-991,1521LC-1 sq
4RP11-113D199p21.3chr9:20,996,400-21,158,4641VMRC-LCDCDKN2A, CDKN2B, MTAP22
RP11-344A79p21.3chr9:21,506,373-21,676,2273VMRC-LCD, LC-1 sq, KNS-62
RP11-11J19p21.3chr9:22,417,726-22,579,7211KNS-62
RP11-782K29p21.3chr9:22,584,981-22,585,3581KNS-62
5RP11-33O159p21.3chr9:22,823,087-22,897,4842KNS-62, LU99ATEK6
RP11-330J239p21.3chr9:25,292,197-25,425,8862KNS-62, LU99A
RP11-55P99p21.3-21.2chr9:25,425,787-25,573,5961LU99A
6RP11-307D1713q21.2chr13:58,727,654-61,368,5641VMRC-LCDPCDH202
7RP11-600P113q31.1chr13:77,973,420-78,566,3211VMRC-LCP4
RP11-25J2313q31.1chr13:78,837,347-79,310,4311VMRC-LCP
RP11-440G413q31.1chr13:81,026,555-81,027,1751VMRC-LCP
RP11-295L1213q31.1chr13:81,571,893-82,147,4601VMRC-LCP
RP11-400M813q31.1chr13:82,201,212-82,280,6531VMRC-LCP
RP11-91O1513q31.1chr13:83,668,529-83,670,1961VMRC-LCP
RP11-118K2013q31.1chr13:83,711,618-83,853,2351VMRC-LCP
RP11-29C813q31.1chr13:84,853,779-85,313,9781VMRC-LCP
RP11-569I2013q31.1chr13:85,891,468-86,093,8921VMRC-LCP
RP11-29P2013q31.2chr13:86,796,651-87,270,5001VMRC-LCP
RP11-27D913q31.2chr13:87,913,237-88,370,3881VMRC-LCP
RP11-114G113q31.3chr13:88,656,527-89,117,3051VMRC-LCP
RP11-86C313q31.3chr13:88,883,889-89,379,5781VMRC-LCP
RP11-79H713q31.3chr13:89,556,363-90,080,6361VMRC-LCP
8RP11-72J713q32.2chr13:97,465,157-97,495,7691VMRC-LCDEBI210
RP11-19J1413q32.2chr13:97,851,595-97,851,7571VMRC-LCD
RP11-122A813q32.3chr13:98,471,182-98,644,5171VMRC-LCD
9RP11-134G2220p12.1chr20:15,224,211-15,251,4442SK-LC-3, KNS-620
RP11-65G1820p12.1chr20:15,271,770-15,375,9031SK-LC-3
RP11-11O1520p12.1chr20:15,567,963-15,728,7581SK-LC-3
  • * Based on UCSC Genome Browser, May 2004 Assembly.

  • Possible tumor-suppressor genes located around BAC.