Table 1.

The chemopreventive effect of NO-ASA against pancreatic cancer in hamsters

Incidence (% decrease)Multiplicity (mean ± SE; % decrease)Histologic score (%)
NormalPanIN1APanIN1BPanIN2PanIN3Cancer
BOP/vehicle (n = 15)53.30%1.00 ± 1.410020.013.313.353.3
BOP/ASA (n = 15)41.2% (22.7)0.71 ± 1.10 (↓29%)011.817.623.55.941.2
BOP/NOASA (n = 17)5.9% (88.9) *0.06 ± 0.24 (↓94%) 011.841.229.411.85.9
  • * Statistically significant reduction compared with vehicle (P = 0.003) or ASA (P = 0.015); no significant difference between ASA and vehicle groups.

  • Statistically significant reduction compared with vehicle (P < 0.05).