Table 3.

OR of pancreatic cancer (stratified by BMI and smoking) by plasma concentrations of folate, vitamin B6, vitamin B12, and homocysteine in quartiles among 208 cases and 623 controls (including multivitamin users)

Plasma one-carbon nutrientAll four cohorts combined
Q1Q2Q3Q4PtrendQ1Q2Q3Q4Ptrend
Lower BMI (below the median, <24.7)Higher BMI (above the median, ≥24.7)
Folate
    Cases/controls23/8123/7818/7630/8130/8424/9029/4829/76
    Multivariable OR1.01.12 (0.57–2.22)0.83 (0.41–1.71)1.36 (0.70–2.62)0.361.00.81 (0.43–1.52)1.96 (1.02–3.77)1.06 (0.57–1.96)0.60
Vitamin B6
    Cases/controls27/7121/6127/9720/9131/8320/7132/7529/71
    Multivariable OR1.00.89 (0.44–1.83)0.73 (0.38–1.39)0.56 (0.28–1.12)0.031.00.78 (0.40–1.52)1.16 (0.63–2.12)1.13 (0.60–2.11)0.50
Vitamin B12
    Cases/controls22/7527/7729/8217/8525/7928/7835/7425/70
    Multivariable OR1.01.25 (0.65–2.41)1.27 (0.66–2.43)0.66 (0.32–1.36)0.251.01.17 (0.61–2.23)1.59 (0.85–2.97)1.17 (0.60–2.28)0.60
Homocysteine
    Cases/controls19/9927/7021/6627/8421/7028/6231/7233/98
    Multivariable OR1.02.00 (1.02–3.94)1.71 (0.84–3.49)1.61 (0.81–3.21)0.291.01.57 (0.78–3.15)1.63 (0.83–3.23)1.07 (0.55–2.06)0.89
Never smokersPast/current smokers
Folate
    Cases/controls19/5423/6418/5017/6134/11024/10329/7442/96
    Multivariable OR1.01.06 (0.51–2.24)1.06 (0.48–2.33)0.88 (0.40–1.92)0.641.00.78 (0.43–1.42)1.42 (0.79–2.57)1.56 (0.90–2.70)0.05
Vitamin B6
    Cases/controls23/4613/5623/6818/6335/10828/7536/10331/99
    Multivariable OR1.00.51 (0.23–1.15)0.71 (0.35–1.46)0.66 (0.31–1.43)0.461.01.15 (0.64–2.08)1.15 (0.67–2.00)1.01 (0.57–1.77)0.64
Vitamin B12
    Cases/controls15/6623/5525/5315/5932/8732/10039/10227/96
    Multivariable OR1.01.95 (0.92–4.16)2.26 (1.06–4.83)1.20 (0.53–2.71)0.731.00.86 (0.48–1.54)1.05 (0.60–1.84)0.75 (0.41–1.37)0.42
Homocysteine
    Cases/controls18/7822/5319/4118/6122/9133/7933/9642/120
    Multivariable OR1.01.81 (0.87–3.76)2.07 (0.94–4.56)1.18 (0.54–2.54)0.611.01.81 (0.96–3.42)1.42 (0.76–2.65)1.40 (0.77–2.54)0.57
  • NOTE: ORs were, in addition to matching variables [year of birth, cohort membership (NHS, HPFS, PHS, WHI), smoking status (current, past, or never), fasting status, and month of blood draw], further adjusted for gender, BMI, physical activity, and a history of diabetes mellitus.