Table 1.

hCDC4 and NOTCH1 mutations in primary T-ALL and hematologic cell lines

hCDC4NOTCH1-HDNOTCH1-PEST
Patient no.
    1wtwtwt
    2wtwtwt
    3wtwtwt
    4wtwtwt
    5wtwtwt
    6wtwtwt
    7wtwtwt
    8wtwtwt
    9wtwtwt
    10wtwtwt
    11wtwtwt
    12wtwtwt
    13<PM> R465Hwtwt
    14<PM> R465Hwtwt
    15<PM> R465Hwtwt
    16<PM> R479Gwtwt
    17<PM> R689Wwtwt
    18<PM> R479Qwtwt
    19<PM> R479L<PM> R1599Pwt
    20<PM> R479G<PM> R1599P<Del> S2426X
    21wt<PM> L1586P<Ins> P2476X
    22wt<PM> L1594P<Del> Q2504X
    23wt<PM> L1601Pwt
    24wt<Ins> K1608 VRVTHTKwt
    25wt<PM> L1575Pwt
    26wtwt<PM> T2484M
Cell line
    T-ALL (T)wtwtwt
    PEER (T)wtwtwt
    Molt17 (T)wtwtwt
    CCRF-CEM (T)<PM> R465C<Ins> R1595 <PRLPHNSSFHFL><PM> P2413S
    Jurkat (T)<PM> R505Cwtwt
    JM (T)<PM> R505C<PM> R1628Qwt
    P12 ISHIKAWA (T)<PM> R505C<Ins> A1708 ARLGSKNIPYKIEAwt
    DND41 (T)wt<PM> L1594P<Ins> D2443X
    Molt4 (T)wt<PM> L1601P<Del> P2515X
    Reh (pre-B)wtwtwt
    RS4 (pre-B)wtwtwt
    Daudi (BL)wtwtwt
    DG75 (BL)wtwtwt
    U266-1984 (MM)<PM> R505Cwtwt
    K562 (CML)wtwtwt
  • Abbreviations: PM, point mutation; Del, deletion; Ins, insertion; T, T-cell line; pre-B, pre–B-cell line; BL, Burkitt's lymphoma cell line; MM, multiple myeloma cell line; CML, chronic myelogenous leukemia cell line.