Table 2.

Associations of SNPs in inflammation pathway genes with lung cancer

SNP name *IdentifierSubjects with data, NMutant allele frequency, %HeterozygoteHomozygote for mutant allelePtrendCombined heterozygote and homozygote mutant
CasesControlsCasesControlsOR (95% CI) OR (95% CI) OR (95% CI) P
Proinflammatory cytokines, receptors, and related molecules
    IL1A C-889Trs18005871,5331,70031.128.21.21 (1.05–1.41)1.23 (0.96–1.58)0.011.22 (1.06–1.40)0.006
    IL1A Ala114Serrs175611,5371,70730.327.81.17 (1.01–1.36)1.21 (0.94–1.57)0.031.18 (1.03–1.36)0.02
    IL1B C-511Trs169441,5261,69632.934.40.92 (0.79–1.07)0.88 (0.70–1.11)0.200.91 (0.79–1.05)0.21
    IL1B T-31Crs11436271,5341,70732.834.40.92 (0.79–1.06)0.86 (0.68–1.09)0.140.91 (0.79–1.04)0.17
    IL1B C3954Trs11436341,5381,70523.920.91.26 (1.09–1.47)1.32 (0.96–1.83)0.0021.27 (1.10–1.47)0.001
    IL1R1 Ala124Glyrs22281391,5321,7086.46.51.00 (0.80–1.24)0.90 (0.30–2.72)0.930.99 (0.80–1.23)0.95
    IL2 T-330Grs20697621,5251,69329.330.11.00 (0.86–1.16)0.93 (0.71–1.20)0.680.99 (0.86–1.13)0.84
    IL2RB Asp391Glurs2289421,5231,69517.518.80.91 (0.78–1.06)0.86 (0.57–1.28)0.170.90 (0.78–1.05)0.17
    IL6 G-174Crs18007951,5321,69841.342.30.94 (0.81–1.10)0.96 (0.79–1.18)0.620.95 (0.82–1.10)0.48
    IL6R Asp358Alars81922841,5391,70439.339.30.97 (0.83–1.13)1.01 (0.82–1.25)0.960.98 (0.85–1.13)0.75
    IL8 T-251Ars40731,5221,70353.854.71.00 (0.84–1.20)0.93 (0.77–1.14)0.450.97 (0.82–1.16)0.77
    IL8RA Ser276Thrrs22346711,5361,7065.44.81.15 (0.91–1.46)1.48 (0.39–5.65)0.201.16 (0.92–1.46)0.22
    IL12B A1188Crs32122271,5301,69019.620.60.89 (0.77–1.04)1.03 (0.72–1.48)0.330.91 (0.78–1.05)0.20
    IL12RB Met365Thrrs3759471,5321,70533.031.51.04 (0.89–1.20)1.15 (0.91–1.45)0.271.06 (0.92–1.22)0.42
    IL16 T-295Crs47788891,5371,71019.220.70.84 (0.72–0.98)1.09 (0.76–1.55)0.180.87 (0.75–1.00)0.06
    IL16 Asn446Lysrs178755351,5301,70726.926.41.01 (0.88–1.18)1.11 (0.84–1.48)0.541.03 (0.89–1.18)0.69
    TNFA T-1031Crs17999641,5351,70521.921.90.97 (0.84–1.13)1.04 (0.74–1.47)0.920.98 (0.85–1.13)0.80
    TNFA T-857Crs17997241,5001,67512.111.21.05 (0.86–1.29)1.15 (0.82–1.62)0.361.08 (0.90–1.29)0.42
    TNFA G-308Ars18006291,5331,70116.916.31.05 (0.90–1.23)1.05 (0.68–1.61)0.551.05 (0.90–1.22)0.54
    TNFA A-238Crs3615251,5391,7105.95.31.21 (0.97–1.52)0.38 (0.08–1.92)0.221.18 (0.95–1.48)0.14
    TNFB Arg13Cysrs28577131,5071,67528.228.60.90 (0.78–1.04)1.07 (0.82–1.41)0.630.93 (0.80–1.07)0.29
    TNFB His51Prors30935431,5271,6896.56.80.92 (0.74–1.14)1.57 (0.58–4.28)0.700.94 (0.76–1.16)0.55
    TNFR1 G-610Trs41495701,2741,43729.028.51.04 (0.89–1.22)0.611.04 (0.89–1.22)0.61
    TNFR1 Arg121Glnrs41495841,5261,6962.12.20.92 (0.65–1.30)0.640.92 (0.65–1.30)0.64
    TNFR2 Met196Argrs10616221,4901,64023.023.30.99 (0.85–1.15)1.02 (0.73–1.40)0.980.99 (0.86–1.15)0.93
    TNFR2 Glu232Lysrs57460261,4661,6223.33.80.88 (0.66–1.16)0.360.88 (0.66–1.16)0.36
    IFNAR1 Val168Leurs22571671,5391,70513.914.11.01 (0.85–1.19)0.87 (0.56–1.34)0.770.99 (0.85–1.17)0.93
    IFNAR2 Phe10Valrs72790641,5341,71230.732.50.89 (0.77–1.03)0.85 (0.66–1.08)0.080.88 (0.77–1.01)0.08
    IFNG T-1615Crs20697051,5361,70534.434.50.99 (0.85–1.15)1.03 (0.82–1.29)0.921.00 (0.86–1.15)0.95
    IFNG A874Trs24305611,5211,69244.144.50.98 (0.83–1.15)0.94 (0.77–1.15)0.570.97 (0.83–1.13)0.67
    GM-CSF T-1916Crs20696141,5271,69643.143.81.01 (0.86–1.19)0.93 (0.76–1.14)0.570.99 (0.85–1.15)0.90
    GM-CSF Ile117Thrrs258821,4841,61321.119.21.14 (0.98–1.33)1.26 (0.87–1.83)0.051.16 (1.00–1.34)0.06
    MCP1 A-2518Grs10246111,5351,69926.328.20.94 (0.81–1.09)0.77 (0.59–1.01)0.080.91 (0.79–1.05)0.18
    MIF G-173Crs7556221,5301,69017.416.81.01 (0.86–1.18)1.24 (0.82–1.86)0.511.03 (0.89–1.20)0.70
Anti-inflammatory cytokines, receptors, and related molecules
    IL4 C-590Trs22432501,4851,63114.814.01.10 (0.93–1.30)1.06 (0.65–1.75)0.311.09 (0.93–1.29)0.27
    IL4 5′-UTR(C/T)rs20708741,5391,70914.814.21.03 (0.88–1.22)1.22 (0.76–1.96)0.461.05 (0.89–1.23)0.57
    IL4R Ile75Valrs18050101,5411,70645.846.30.93 (0.79–1.10)0.96 (0.79–1.17)0.650.94 (0.81–1.10)0.43
    IL4R Glu400Alars18050111,1771,3770.10.02.87 (0.25–32.7)0.402.87 (0.25–32.7)0.40
    IL4R Ser503Prors18050151,5311,69417.717.21.08 (0.92–1.26)0.90 (0.60–1.37)0.651.06 (0.91–1.23)0.46
    IL4R Gln576Argrs18012751,5361,70422.021.41.03 (0.89–1.19)1.06 (0.76–1.47)0.651.03 (0.89–1.19)0.67
    IL4R Ser752Alars18050161,5121,6746.15.91.03 (0.83–1.30)0.93 (0.33–2.61)0.831.03 (0.83–1.28)0.79
    IL5 C-745Trs20698121,4751,62428.430.20.97 (0.84–1.13)0.75 (0.57–0.97)0.090.93 (0.81–1.07)0.32
    IL10 A-1082Grs18008961,5241,69348.749.50.94 (0.79–1.12)0.94 (0.77–1.15)0.540.94 (0.80–1.10)0.46
    IL10 C-819Trs19008711,5071,6960.80.61.43 (0.78–2.63)0.241.43 (0.78–2.63)0.24
    IL10 C-592Ars18008721,5311,69222.823.40.92 (0.79–1.07)1.00 (0.73–1.37)0.450.93 (0.80–1.07)0.31
    IL10RA Ser159Glyrs31359321,5401,70916.417.40.95 (0.81–1.11)0.80 (0.54–1.20)0.270.93 (0.80–1.09)0.37
    IL10RB Lys47Glurs28341671,5341,70426.224.81.02 (0.88–1.18)1.24 (0.93–1.67)0.271.05 (0.91–1.21)0.50
    IL13 C-1112Trs18009251,5281,69521.920.61.06 (0.91–1.23)1.33 (0.94–1.88)0.141.08 (0.94–1.25)0.27
    IL13 Arg130Glnrs205411,5361,70720.119.61.11 (0.95–1.29)0.92 (0.65–1.29)0.531.08 (0.93–1.25)0.29
Prostaglandins and nitric oxide
    COX2 G-765Crs204171,5161,68317.417.40.97 (0.83–1.14)0.96 (0.63–1.44)0.700.97 (0.83–1.13)0.70
    COX2 3′-UTR(T/C)rs52751,5041,68434.835.80.93 (0.80–1.09)0.88 (0.70–1.10)0.220.92 (0.80–1.06)0.27
    COX2 3-'UTR(C/T)rs6894701,5371,7063.22.91.02 (0.75–1.38)1.93 (0.45–8.27)0.651.04 (0.78–1.41)0.77
    INOS Leu608Serrs22975181,5301,70819.218.51.15 (0.98–1.34)0.84 (0.57–1.24)0.411.11 (0.96–1.29)0.16
    ENOS Glu298Asprs17999831,4791,63033.232.81.04 (0.89–1.21)1.04 (0.82–1.32)0.641.04 (0.90–1.20)0.61
Intracellular signaling molecules
    IKB C-420Trs22334091,5241,69023.423.30.92 (0.80–1.07)1.11 (0.81–1.53)0.750.95 (0.82–1.09)0.44
    IKB 3′-UTR(C/T)rs89041,5311,70536.237.61.02 (0.87–1.18)0.85 (0.68–1.06)0.290.98 (0.85–1.13)0.74
    PPARA Leu1162Valrs18002061,5421,7126.56.11.13 (0.91–1.39)0.81 (0.21–3.06)0.351.12 (0.90–1.38)0.31
    PPARD 5′-UTR(T/C)rs20165201,5311,69820.118.01.21 (1.04–1.42)1.15 (0.80–1.66)0.021.21 (1.04–1.40)0.01
    PPARG Pro12Alars18012821,5291,70311.212.00.97 (0.81–1.15)0.62 (0.33–1.14)0.290.94 (0.79–1.11)0.47
  • NOTE: Abbreviations for SNP names are standard and can be referenced to the rs identifier.

  • * The SNP allele specified second is the less common allele, called the “mutant” allele.

  • ORs are in reference to subjects homozygous for the wild-type allele and are adjusted for sex, age, and logcig-years as a measure of cumulative tobacco exposure (see Materials and Methods). ORs that differ significantly from 1.00 are underlined. P < 0.05 are underlined.