Table 3.

Associations with lung cancer for interleukin 1 receptor antagonist gene VNTR polymorphisms

IL1RN VNTR genotype *Cases, n (%)Controls, n (%)OR (95% CI)
44828 (56.3)908 (55.8)1.00
22118 (8.0)118 (7.3)1.09 (0.83–1.43)
24449 (30.5)509 (31.3)0.99 (0.84–1.16)
2519 (1.3)18 (1.1)1.28 (0.66–2.48)
4545 (3.1)58 (3.6)0.86 (0.57–1.29)
Other13 (0.9)15 (0.9)0.99 (0.46–2.11)
  • NOTE: Results were available for 1,472 cases and 1,626 controls.

  • * IL1RN genotype refers to the number of 86-bp repeats present in the intron of each copy of the gene (e.g., 24 refers to two repeats on one chromosome and four repeats on the other chromosome). “Other” VNTR genotypes include 23 (1 case, 1 control), 33 (3 cases, 1 control), 34 (4 cases, 6 controls), 46 (2 cases, 2 controls), and 55 (3 cases, 5 controls).

  • ORs are adjusted for age, sex, and logcig-years as a measure of cumulative tobacco exposure (see Materials and Methods).