Table 4.

Associations with lung cancer for haplotypes of IL1A and IL1B on chromosome 2q13

Haplotype *Case haplotypes, n (%)Control haplotypes, n (%)OR (95% CI)
w-w-w-w-w1,113 (47.3)1,316 (48.9)1.00
w-w-w-m-m561 (23.8)715 (26.5)0.93 (0.81–1.06)
m-m-m-w-w368 (15.6)370 (13.7)1.18 (1.00–1.39)
m-m-w-w-w139 (5.9)134 (5.0)1.23 (0.96–1.58)
m-m-w-m-m48 (2.0)65 (2.4)0.87 (0.60–1.28)
w-w-m-w-w76 (3.2)50 (1.9)1.80 (1.25–2.59)
m-m-m-m-m32 (1.4)31 (1.2)1.22 (0.74–2.01)
Other17 (0.7)13 (0.5)1.55 (0.75–3.20)
  • NOTE: The table shows haplotypes for 1,177 cases and 1,347 controls (2,354 haplotypes for cases, 2,694 haplotypes for controls). Overall, haplotypes differ significantly between cases and controls (P = 0.004).

    Abbreviations: w, wild-type allele; m, mutant allele.

  • * Haplotypes refer to the wild-type and mutant alleles for polymorphisms in the following order: IL1A Ala114Ser, IL1A C-889T, IL1B C3954T, IL1B T-31C, and IL1B C-511T.