Table 1.

Protein sequence of human cyclin B1 (National Center for Biotechnology Information accession number NM_031966) aligned with that of human HER4/s80HER4, human HER1, human HER2, and human HER3

Protein nameAmino acid no. *Sequence
Cyclin B140–60RPRTALGDIGNKVSEQLQAKM
HER4/s80HER4990–1,010DDRMKLPSPNDSKFFQNLLDE
HER4db/s80db990–1,010DDaMKaPSPNDSKFFQNLLDE
HER1/EGFR960–980DERMHLPSPTDSNFYRALMDE
HER2/ErbB2992–1,012ED-LGP-ASPLDSTFYRSLLED
HER3/ErbB3930–950SGPGIAPGPEPHGLTNKKLEE
  • NOTE: Residues defining the D-box are bolded and italicized. Site-directed mutagenesis was done to generate R-to-A and L-to-A mutations, shown in lowercase.

  • * Alignment of ErbB sequences according to ref. 40.